To estimate myoelectric activity of gastroduodenal area chronic experiments were performed in 4 sheep with bipolar platinum electrodes attached to the antral and small intestinal wall. Myoelectrical activity was recorded by means of multichannel electroencephalograph. The study concerned role of muscarinic receptor subtypes in motor activity antroduodenal area in sheep. During experiments antagonists of muscarinic receptors (M) were administered intravenously. From antagonists of muscarinic receptors were used: atropine sulfate, and selective antagonists of muscarinic receptors – antagonists of M₂ receptors gallamine triethiodide and methoctramine tetrahydrochloride, antagonist of M₃ receptors 4-DAMP methiodide and antagonist of M₄ receptors tropicamide in doses 0,05, 0,1 and 0,2 mg/kg. All used antagonists abolished myoelectric activity in tested area and had the significant influence on frequency of minute rhythm (RM). Receptor subtypes M₂, M₃ i M₄ play the role in control of motor activity of antoduodenal area. Muscarinic receptor subtypes participate in regulation of RM.

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