Title
ABILITIES OF SCLEROPHOMA PYTHIOPHILA AND EPITHYRIUM RESINAE CULTURES TO TRANSFORM STEROID HORMONES AND THEIR ESTERS
Autor
Ewa Brzezowska, Jadwiga Dmochowska-Gładysz, Tadeusz Kowalski
Keywords
testosterone, 19-nortestosterone, 17β-oxidation, selective reduction of C1-C2 double bond
Abstract
Two species of fungi: Sclerophoma pythiophila and Epithyrium resinae occurring on forest trees were used as bioreagents in transformations of steroid substrates. The fungi have been shown to oxidize steroid hormone – testosterone and anabolic agents – 19-nortestosterone and 1-dehydrotestosterone. S. pythiophila and E. resinae, were also used to investigate the transformations of testosterone and 19-nortestosterone esters: propionate, isobutyrate testosterone and propionate, phenylopropionate 19-nortestosterone. Besides 17β oxidation, which was observed in all examined substrates, additionally in E. resinae culture, selective reduction of C1-C2 double bond in 1-dehydrotestosterone was observed. Hydrolysis reactions for all testosterone and 19-nortestosterone esters was noticed.
Pages
13-19
Cite
Brzezowska, E., Dmochowska-Gładysz, J., Kowalski, T. (2005). ABILITIES OF SCLEROPHOMA PYTHIOPHILA AND EPITHYRIUM RESINAE CULTURES TO TRANSFORM STEROID HORMONES AND THEIR ESTERS. Acta Sci. Pol. Biotechnol., 4(1-2), 13-19.
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