This article describes both ethiology and clinical signs of inherited diseases in people and animals which are related to insufficient biosynthesis of adrenocortical steroids. In human medicine the most often diagnosed disease of such kind is Congenital Adrenal Hyperplasia due to 21-steroid hydroxylase deficiency but also due to impaired activity or deficiency of further enzymes involved in corticosteroidogenesis. Inherited disorders of steroid biosynthesis similar to human diseases are also present in domestic animals.

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