The purpose of the study was to determine the changes in the distribution of „endogenic” iron in rabbit tissue and body fluids after the administration of ditiocarb sodium (DTC).The study was conducted on clinically healthy mongrel rabbits. Two groups were administered DTC intravenously: the first one at the low dose of 20 mg/kg b.w. and the latter at the high dose of 200 mg/kg b.w. The control group was animals administered saline solution ( sodium chloride). After euthanasia ,in 72^nd hour after injection of DTC samples of liver, kidneys, brain, skeletal muscles, perirenal fat, urine and blood were taken and mineralised dry in a muffle furnace at 450 0C. Iron was determined directly in mineralisate by the atomic spectrophotometry on a Pye Unicam SP-9 apparatus. The results obtained were subjected to statistical analysis by the Student t-test. Animals given low dose of DTC were having statistically related decrease of iron in fat, urine and plasma,and unrelated in liver,muscle and blood. After the administration of high doses of DTC (200 mg/kg b.w.) „endogennic” iron level were having statistically related increase in kidneys and unrelated in brain,liver, urine and plasma. In addition, it has been found, statistically relevant ,decrease iron level in adipose. The results of the study indicate that DTC administered intravenously in rabbits at the dose of 20 or 200 mg/kg b.w. leads to the substantial redistribution of iron in tissues and body fluids.

59-65