The aim of the present work was a detection of bacterial antigen in carps liver, kidney and spleen . Fish were immunised intra peritoneal by Aeromonas hydrophila bacterial antigen. 60 carps were divided into two experimental groups (I and II) 30 carps from the group I were injected 5x10⁷ml^–1 killed bacterial suspension, 30 from group II injected i. p. with the same bacterial suspension with adjuwant Emulsigen. Samples were taken for immunohistochemistry after 12, 72 hours, 1 and 2 weeks and after 1 and 3 months. We have shown that this method allowed to early detection of bacterial antigens in internal organs samples.

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