Serum protein alterations in dogs (n = 21) with Ehrlichia canis infection determined by indirect fluorescent antibody test IFAT (titres 1:20 to 1:1280) were studied. Compared to the control group of 20 clinically healthy dogs (with the negative results in IFAT), significant decreases in the mean concentration of total protein (p≤0,05), albumin ((p≤0,001), albumin/globulin ratio (p≤0,001) and gamma globulin (p≤0,001) in the infected group were determined. In contrast alpha-2 globulin and beta globulin fractions were significantly higher in infected group. In conclusion, serum protein profile can be used in the clinically diagnosis of monocytic canine ehrlichiosis as a supplementary examination, comparable with haematological or blood smears examinations.

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