Studies on the influence of pesticides on immune system functions focus on the assesment of their direct toxicity on the immunocompetent cells. Roundup (containing 41% gliphosate) is a herbicide used against weeds in agriculture and aquaculture. In the study the influence of gliphosate on metabolic and phagocytic activity of PMN and MN cells and proliferative activity of T and B cells in carp and European sheatfish was assessed. In dosis 100 mg·dm^-3 in bath (10 minutes) strongly reduces both metabolic (RBA) and phagocytic (PKA) activity of leucocytes. Also proliferative response of lymphocytes stimulated Con A and LPS was reduced. Fishes with different environmental preferences have similar sensitivity (supressive effect) to the selected xenobiotics.

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