Histological, histochemical and ME lessions after application of cleaning preparation DOMESTOS on the skin surface were described. The experiment was performed on laboratory BALB/c mice. Signifficant differences in intensity and extent of lesions were observed between animals in receiving DOMESTOS group every day by a week. In one of them deep necrosis comprising epidermis and dermis dominate in histological picture, whiles in other only hyperkeratosis or parakeratosis of epithelium was seen. In each case epidermal lesions were correlated with edema and inflammatory infiltration of subcutaneous connective tissue. After week lasting cease of superficial DOMESTOS application, necrotic lessions disappeared but different degree of hyperkeratosis were continually present. As well edema and inflammatory lesions in subcutaneous tissue remains microscopicaly well visible.

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