The study was conducted on 20 multiparous crossbreed Black and White x HF (50% share of Holstein Friesian blood) lactating dairy cows (2^rd-4^th lactation) with body weights of 650 ± 30 kg, during the first months of lactation and the milk yield 4 500-6 500 kg in previous lactation. The cows were assigned by an analogue method into 2 groups (10 cows in each), by making allowances for age, body weight, number of lactation, and the milk yield in previous lactation. The metabolic profiles and daily milk yield were examined on cows which were calved in winter feeding period (March) and in summer feeding period (July) in I and II month of lactation. The production rations were composed with maize and beet-top silage, lucerne with grasses hay, wheat ground, dried sugar beet pulp, molasses, wheat straw, lucerne with grasses g7reen and grasses pasture green. Mineral supplement were used occasionally. The mean level of glucose, calcium, phosphorus inorganic, magnesium and total protein in the blood serum were significantly less than the references data (2.66; 2.40; 1.64; 0,86 mM·L^-1 i 72.0 g·L^-1) and the lowest level were 2.03; 2.19; 1.22; 0.85 mM·L^-1 i 65.0 g·L^-1. The occurrences of ketone compound in milk in the I month of lactation in both groups were found. In II month of lactation the average daily milk yield of cows were significantly (p < 0.05) decreased by 2.0 kg (1.3 kg in winter and 2.7 kg in summer-time) and the predicted milk yield peak of lactation curve in the first month of lactation was disappeared. Supplement treatment feeds were considered and recommended for the prevention of production diseases. The metabolic profiles and daily milk yield control, may be very useful to protected of health and productivity of high yielding dairy caws in first months of lactation, when it is the integrity part of preventive medicine plane.

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