In the present study we explored the effect of sinigrin after one and two weeks treatment on lipid metabolism and changes of plasma thyroid hormone levels (T3, T4, fT3, fT4). The experiment was conducted in vivo on 32 male Wistar rats with an initial body weight of 140 ? 5g. The animals were divided into 4 groups (n=8) and were maintained under standard conditions. Sinigrin was given during one and two weeks. The animals from two control groups were given water intragastrically in dose 1ml?100g–1 body weight. The sinigrin was dissolved in water and was given in dose 2mg?100g–1 body weight by oral administration during one and two weeks. Body weights of the individual rats were recorded every two days. After appropriate time the animals were decapitated and their serum and liver were collected for analysis. The serum was used for the estimation of plasma thyroid hormones levels, free fatty acids, triglyceride, phospholipids, total, free and esterified cholesterol contents. This experiment has shown that when sinigrin was given to rats in that dose 2 mg?100g–1 b.w. it was a material factor interfering with lipid metabolism. It pertained to influence of sinigrin only after two weeks treatment. Sinigrin administration increased significantly free fatty acids, total cholesterol and estrificated cholesterol concentration. On the contrary the level of triglycerides was decreased considerably. These changes were not significant at group of animals being fed of sinigrin during one week but in this group of rats the considerable increase of T3 was noticed in serum in comparison with control group.

113-119