Feline chronic gingivostomatitis (FCG) is currently one of the most serious problems in feline internal medicine [Southerden and Gorrel 2007]. It manifests with a strong inflammation of mucosal membrane of oral cavity with or without the presence of dental plaque and calculus, what causes difficulties in food administration, weight loss and apathy [Lommer 2003]. The cause of the illness occurrence is not clearly defined. The possibility of bacterial, viral as well as environmental (nutrition and maintenance) factors’ participation in the disease etiology is considered [Lyon 2005, Norris and Love 1999]. As the etiology of the disease and the predisposing factors are not explicitly defined, it is necessary to develop the treatment scheme, which will allow minimizing the consequences of the disease and retraction of the clinical signs. Among the pharmacological treatment methods proposed to inhibit the pathological process use of different forms of chlorhexidine, antibiotics, immunomodulators, corticosteroids, progestagenes and gold salts [Gorrel 2007, Zetner et al. 2007] and feline interferon omega [Southerden and Gorrel 2007, Zetner et al. 2007] are mentioned. The premolar and molar teeth extraction is one of the treatment methods [Hennet 1997]. It is an extreme solution, which should be taken up only when other treatment methods do not give satisfying results. This article describes a pharmacological treatment method in cats with diagnosed chronic gingivostomatitis, consisting in combination of local and general treatment. 22 cats divided into two groups underwent the treatment. After the oral sanitation animals from group I gradually received local and general drugs and animals from group II underwent a combined therapy. The evaluation on each stage of treatment shown higher efficacy of combined treatment.

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