One of the most important elements of homeostasis regulation is keeping a constant level of glucose in the blood. Concentration of this carbohydrate is regulated by a few different factors, mainly by insulin. However, the last research indicates the important role of another factors, too. In this article we present results of the experiments with using glucagon-like peptide-1, a peptide secreted and released from lower intestine cells, called L-cells. Experiments were provided on 48, male Wistar rats, weighting about 200 g. The in situ pancreas perfusion method was used in these research. Rats were divided into 8-rats groups, and pancreases were perfused with buffer containing 3 different glucose levels (0; 6.66 and 25 mmol/l) and GLP-1 (100 pmol/l). The results shows the corelations between glucose and insulin levels in the bloob after the stimulation of GLP-1. In the case of no glucose in the basic medium, there was very low level of insulin in the perfuzates. When 25 mmol/l glucose was added we could not conclude anything about GLP-1 stimulation, cause of too strong stimulation by very high glucose concentration. The most markedly observed insulin output was at 6.66 mmol/l.

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