Only single immune-modulation procedure towards the RES of udders belonged to 112 cows from included ~500 individuals herd E, whose milk during recent lactation >400 000 cells/ml was contained, but the effectiveness after their parturition were estimated. This stimulant procedure thorough 5 months after the calving the cytological quality of their milk were improved in comparison to bulk milk from all cows. However, the absence of this treatment repetition on adequate terms was caused that following months their milk gradually were deteriorated when compared to SCC value concerned to other cows (control group). During theses evaluations the linear estimations of DHI exponential series recommended by Nelson Philpot greatly were useful.

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