Filamentous fungi Monascus can produce various secondary metabolites with a polyketide structure, among them there are pigments used for food products. Based on previously conducted studies on the influence of selected cultivating factors on biomass growth and pigments biosynthesis of the filamentous fungus Monascus purpureus DSM 1379 using the “one factor in one time” test procedure, in this study the area response method (RSM) to determine the optimal values of selected substrates is presented. On this basis, the values of glucose and monosodium glutamate were determined to obtain the maximum amounts of pigments which was identified by the measurement of absorbance at 400 nm – yellow pigment and 480 nm – red pigment.

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