The purpose of the study was to examine the influence of ditiocarb sodium (DTC) at a dose of 20 or 200 mg/kg on lead distribution injected once in sub-toxic dose (2 mg Pb/kg i.v.), as a solution of lead acetate. The study was conducted on clinically healthy, mongrel rabbits, divided into 7 groups. Two groups were administered lead acetate; four groups lead acetate and DTC in low or high dose. Control group was intravenously injected with 0.9% saline solution. After euthanasia, at 4^th or 72^nd hour after injection of DTC samples of brain, fat, muscles, liver, kidneys, urine and blood were taken and mineralized dry in a muffle furnace at 450 ºC. Lead was determined by the atomic spectrophotometry on a Pye Unicam apparatus. Clinical observation and histo- and anatomopathological examination simultaneously there were performed. It was proved that intravenously injected DTC simultaneously with lead acetate makes relevant changes in lead distribution in rabbit’s organism. As an effect of DTC-metal interaction brain, adipose and muscles tissue levels of lead raise which are reflected in the increase of toxicity, what was proved by clinical and histo- and anatomopathological examination.

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